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Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos

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Preclinical models converge on immuneinflammatory signaling, HPA axis dysregulation and neurotransmitter alterations as recurrent mechanistic pathways (Ravi et al., 2021

In addition, inflammation can alter the expression of genes involved in mitochondrial function, leading to changes in energy metabolism

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139 The traditional techniques for evaluating the tumor immune microenvironment, including gene expression profiling, flow cytometry, and conventional immunohistochemistry, have limitations