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PRMs in the fluid phase are thought to represent evolutionary precursors to antibodies, offering immune protection and modulation through opsonization, neutralization, enhancement of phagocytosis, and activation of the complement system
Dulaglutides efficacy: in the AWARD trial program, weekly dulaglutide 1.5 mg was shown to reduce HbAc by ~1.0% to 1.5% (baseline ~8.1%) and was superior to placebo and non-inferior or superior to comparators like insulin glargine or Byetta in certain studies ( [6] )
Studies in the pig showed GLP-1 inhibited pancreatic secretion induced by hypoglycemia (central neural stimulation) but not that due to vagal nerve stimulation (126)
But they're slightly different in how they work, as well as in their potential benefits and side effects
doi:10.1016/j.cell.2017.02.031
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