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Shaw I have just completed my 2nd session of sclerotherapy & have already seen results even after my 1st session
Some subjects have lower melanocortin receptor density in hypothalamic nuclei, requiring higher doses to achieve threshold activation
24 weeks helps maintain consistent results
Slower escalation with better tolerance produces better long-term adherence and results than aggressive dosing that causes misery
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As in the LEAN study, the primary outcome is histologic resolution of NASH without worsening of fibrosis after 72 weeks of treatment, while secondary outcomes include improvement in liver fibrosis (1 stage) with no worsening of NASH, NAFLD activity score, as well as multiple serum markers of fibrosis
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