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The placebo-subtracted weight loss was 4.5% for TE 0.25 mg, 9.2% for TE 0.5 mg, and 10.6% for TE 1.0 mg over 24 weeks

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By combining these medications, you are attacking pain from two completely different angles

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Medication review is essentialdose reduction or temporary discontinuation may be necessary if side effects are severe, and concurrent medications (particularly insulin or sulfonylureas) may require adjustment