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Often, the remedy to these and other fatigue-causing factors starts with building solid interpersonal relationships and ongoing communication with the principal investigator (PI) and other trial facilitators

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However, multiple factors, including inflammation (Ahmad et al., 2022) and cerebral perfusion (Wolters et al., 2017) have been supported as early-stage biomarkers for neurodegenerative processes that are receptive to intervention prior to onset of clinically relevant loss in brain function

In addition, neuroprotective strategies targeting mitochondrial dysfunction, oxidative stress, and neuroinflammation and the effects of phytomolecules polyphenols, flavonoids, alkaloids, terpenoids -and GLP-1 mimetics, which have demonstrated significant neuroprotective and metabolic regulatory efficacy in preclinical and clinical models, are included

GLP-1 agonists primarily aid in weight loss and cardiovascular protection, while SGLT2 inhibitors provide strong kidney and heart failure benefits

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