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A two-year clinical trial designed to assess the effect of lipoic acid (1,200 mg/day) on loss of mobility and changes in brain volume in patients with progressive multiple sclerosis is ongoing (85)

Key mechanistic observations from laboratory studies: G-actin sequestration: TB-500 binds monomeric G-actin, regulating the pool available for filament polymerization

This can include brain-based issues

Abrogation of ARF6 in promoting erastin-induced ferroptosis and mitigating capecitabine resistance in gastric cancer cells

250 mg per day of oxidized glutathione (AquaGluta)