doi: 10.1186/s40168-018-0567-4 13 SlatteryCCotterPDO'ToolePW
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About IGF-1R IGF-1R is a transmembrane receptor tyrosine kinase that plays a central role in regulating cell growth, proliferation, differentiation, and survival, and is involved in both normal development and disease pathophysiology
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Chronic activation of NF-B by oxidative stress can promote tumor growth by enhancing cell proliferation and inhibiting apoptosis [105]
The FDA issued a Drug Safety Communication in 2024 stating that their review did not find clear evidence of an increased risk of suicidal thoughts or actions with GLP-1 receptor agonists, though they continue to evaluate this safety concern