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PMID: 27633659

These situations often involve ongoing low-grade inflammation, incomplete previous healing, and adaptive changes in how tissues function

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While PD-1/PD-L1 blockade has demonstrated remarkable success in several cancer types, its efficacy in osteosarcoma remains limited, likely due to the redundant and interconnected nature of immunosuppressive pathways operating within the TME (39)

Better yet, have a colleague check it too