Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S et al
This deliberate tuning of receptor affinity allows the compound to produce balanced activation across all three pathways without overwhelming any single one
Results: Plasma GST protein levels were significantly lower in the AD group than in the CN group (0.94 vs1.05, p = 0.04) and the MCI group (0.94 vs1.09, p 0.05)
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The discovery context tied the compound to delta-wave EEG activity rather than to any specific signalling cascade