Diabetic retinopathy: Interestingly, rapid improvements in blood sugar (from a high baseline) can temporarily worsen diabetic eye disease
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BPC-157 is a 15-residue, 1419.53 g/mol pentadecapeptide whose mechanistic literature centres on local angiogenic signalling, Hsieh and colleagues (J Mol Med, 2017) reported upregulation and internalisation of VEGFR2 in human endothelial cells, and Chang and colleagues (J Appl Physiol, 2011) reported increased FAK and paxillin phosphorylation with greater outgrowth and migration in cultured rat tendon fibroblasts
HCl is responsible for the initial degradation of ingested protein into smaller proteins and protein fragments
First, any GLP-1 produced by intestinal L-cells travels through the bloodstream to the hypothalamus, where it activates GLP-1 receptors that reduce hunger signaling
High levels of circulating cortisol are directly toxic to the reproductive cycle