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Practical tip A combination of SGLT2i and GLP-1RA might theoretically improve cardiorenal benefits in patients with T2D and either ASCVD or multiple risk factors for ASCVD whose A1c remains suboptimal despite initial treatment with only one of these agents or if clinical status changes (e.g., new onset HF or CKD

Small case series and retrospective reviews suggest the combination produces 15-20% body weight loss in patients who didnt respond well to either alone

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