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The first generation of GLP-1 therapies exhibit reduced susceptibility to enzymatic degradation, while providing effective glucose control, improved -cell function, body weight loss and decreased systolic blood pressure in patients with T2D (Meier, 2012) The newly developed incretin mimetics, including albiglutide, dulaglutide and semaglutide, are designed to have extended pharmacokinetic profiles and efficacy suitable once-weekly administration
Functional neurogenesis in the adult hippocampus
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Furthermore, lesser exposure and limited knowledge of T2DM associated with CVD and renal disease may lead to unawareness of the cardiorenal benefits of SGLT2is and GLP-1 RAs among the primary-care physicians [75] compared to a specialist
