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Following the ingestion of carbohydrates and fats, GLP-1 is released and exerts multiple physiological effects essential for maintaining glucose homeostasis ( Metabolically, GLP-1 acts through G protein-coupled receptors to improve insulin sensitivity in muscle and adipose tissues while enhancing -cell function by promoting proliferation and inhibiting apoptosis (see Figure 3)

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IGF-1 is the more stable, longer-lived signal, and it is what many downstream tissues actually respond to