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MiR-27a inhibits the expression of several lipid metabolic genes, including SREBP1-2, FASN, and PPAR/, by reducing lipid synthesis and increasing lipid secretion from cells 92
The liver cells showed large oil and small fat droplets were diffused in ob/ob-GAN NASH mice
SGLT-2 inhibitors were superior to GLP-1RA in reducing the risk of HHF and the renal outcome (24% and 22% lower risk, respectively)
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