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Red blood cells are essential for energy production, nerve health, and red blood cell formation

Damaged endothelial cells and the microparticles they release undergo a loss of membrane lipid asymmetry, leading to the externalization and exposure of negatively charged phosphatidylserine (PS) ( At the cellular level, the interaction between endothelial cells and neutrophils constitutes the core hub of immunothrombosis

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Though IPBC is a relatively uncommon contact allergen, patch testing studies show positive reaction rates ranging from 0.3%-0.9% of patients tested

18 : 573578 Santarelli M, Granato A, Sbriccoli A, Gobbi G, Janiri L, Minciacchi D

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