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The PK profiles of intact AMG 133 (GIPR-Ab with at least one attached GLP-1 analogue peptide) and total AMG 133 (GIPR-Ab with or without GLP-1 analogue peptides) follow a biphasic clearance pattern and demonstrate similar initial concentrations between assays with a gradual divergence over the 2-week study period
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These concerns can be partially mitigated by an intentional lifestyle program, particularly around food
Source: Senaratna et al
Tap water contains microorganisms, minerals, and chlorine that will contaminate and degrade the peptide
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