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PMID: 29756566 View source Malinda KM, et al

It also means the drowsiness effect will hit you during your waking hours, which most patients find disruptive

doi: 10.1038/nrrheum.2012.135 30

These include orlistat, liraglutide, and semaglutide (NICE TA875 for weight management in adults with obesity), as well as GLP-1 receptor agonists within the framework of NICE NG28 (type 2 diabetes management)