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Galletly, C

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Its side-effect profile in trials has broadly mirrored that of other incretin-based therapies, with nausea, vomiting, diarrhoea, and constipation being the most commonly reported adverse effects, particularly during dose escalation

The CBS OPT and L2HGDH OPT were then constructed in pCDH-CMV-Nluc-P2A-copGFP-T2A-Puro (#73037, Addgene), with the Nluc-P2A-coGFP genes removed

We used this model as it may reflect a daily PUFA and iron challenge in humans on a meat-enriched Western diet 19

The finding was further supported by c-met-binding experiments, in which HGF was pre-treated with GSSSG and LASSS at the same molar ratio 1:4000 at which the satellite-cell activation index was rescued to a level comparable to that of non-nitrated regular HGF, as shown in Figure 1d, followed by exposure to peroxynitrite (1:2000) and evaluated for c-met-binding by a sandwich ELISA-like assay on recombinant c-met-Fc chimera (Figure 1e, left column