In vitro cellular senescence models (such as senescence models of human fibroblasts, hepatocytes, and nerve cells) are common tools for studying aging mechanisms and interventional drugs
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The transcription factor FOXO1 plays a crucial role in this process, as DOX exposure activates FOXO1 through cyclin-dependent kinase 2 (CDK2)-mediated phosphorylation
The distinction matters both pharmacologically and legally
This approach not only facilitates the delivery of DSIP into the brain but also highlights the potential of brain-homing peptides as effective carriers for small molecule drugs, targeting brain parenchyma directly and efficiently
They also pointed to other statistical limitations and concluded that more research is needed to confirm the clinical effectiveness of ALCAR [40]