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In vitro cellular senescence models (such as senescence models of human fibroblasts, hepatocytes, and nerve cells) are common tools for studying aging mechanisms and interventional drugs

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The transcription factor FOXO1 plays a crucial role in this process, as DOX exposure activates FOXO1 through cyclin-dependent kinase 2 (CDK2)-mediated phosphorylation

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The distinction matters both pharmacologically and legally

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This approach not only facilitates the delivery of DSIP into the brain but also highlights the potential of brain-homing peptides as effective carriers for small molecule drugs, targeting brain parenchyma directly and efficiently

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They also pointed to other statistical limitations and concluded that more research is needed to confirm the clinical effectiveness of ALCAR [40]

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