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The control group scored a mean of 7.5 out of 10, while the cases averaged 7.0, a statistically significant difference (P=0.046) even when adjusting for diabetes status
tobacco use within 3 months of enrollment
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and catechol- O -methyl transferase (COMT) inhibitors that inhibit degradation of levodopa in the periphery, such as entacapone and opicapone [50]