Intramuscular B12 injections deliver the vitamin directly into the bloodstream, bypassing the digestive system and achieving 70 to 80% greater bioavailability compared to oral supplements
The human evidence is more limited and more mixed
Those two figures are not interchangeable the 50 mg vials dose is roughly 17 larger so a dose is always drawn against the concentration of the specific vial in front of you, never carried over from one vial size to another
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In these situations, oral B12 supplements are often useless because the digestive system can't properly absorb the nutrient
Your gut has a limited transport system, and once that system is saturated, the rest of the dose relies on passive diffusion, which is very inefficient