When used as a treatment option, semaglutide functions by: Stimulating insulin secretion while inhibiting glucagon release
Diarrhea from semaglutide typically occurs during the initial weeks of treatment or when doses are increased, and most cases diminish over time as the body adapts to the medication
However, vertigo the sensation of spinning or rotational movementis not specifically listed as a recognised adverse effect of tirzepatide in the UK SmPC, though spontaneous reports may still occur
Is B-complex only for neurological support
Severity Grading: A Practical Framework No single validated scale exists specifically for GLP-1 injection site reactions, but the NCI Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 skin toxicity grading offers a workable reference: Grade 1 (mild): Erythema or induration 5 cm, skin breakdown, or any systemic involvement
They usually peak after a dose increase and ease within 12 weeks