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Challenges and prospects Despite numerous breakthroughs in stem cell therapy, significant challenges remain for its advancement

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Early coagonists showed improved glucose tolerance and lipid metabolism alongside weight loss driven by both reduced food intake and increased energy expenditure, such as cotadutide, a daily injectable, improves liver metabolism and has reduced HbA1c in clinical trials while also showing kidney-protective effects (e.g., reduced albumin-to-creatinine ratio)