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FIGURE 1 Glucagon-Like Peptide-1 Receptor/Mitogen-Activated Protein Kinase Signal Pathway Mitogen-activated protein kinase (MAPK) belongs to silk/threonine protein kinase, mainly including extracellular signal-regulated kinase (Erk1/2), Jun N-terminal kinase (JNK) subfamily, p38 mitogen-activated protein kinase and ERK5 ( via GLP-1R (Figure 1)

Natural vs Synthetic Intervention Philosophies Functional medicine practitioners generally favor natural approaches that support the body's inherent healing mechanisms rather than forcing specific physiological responses through synthetic interventions

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Among 182 cases identified, patients were predominantly aged 4060 years, with exenatide accounting for 24.2% of reports, followed by semaglutide (21.4%)

For immunohistochemistry, detection was performed using a biotinylated anti-rabbit IgG secondary antibody and streptavidin-Horseradish peroxidase (HRP), followed by colorimetric detection using DAB