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IGF-1 LR3 IGF-1 LR3, or Insulin-Like Growth Factor-1 Long Arg3, is a more potent version of the naturally occurring hormone IGF-1

In recent years, clinical studies found that GLP-1 receptor agonist (GLP-1 RAs) and its analogues can significantly improve bone metabolism in diabetes patients, promoting osteoblastic differentiation, and play an anti-diabetic osteoporosis role ( However, there are few studies on the impact of GLP-1 RAs on the incidence rate of osteoporosis

In the case of Ozempic and Wegovy, the shortage began in 2022 when the manufacturer, Novo Nordisk, could not supply adequate quantities of the drug to meet demand

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