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doi:10.1177/03635465251357593

Activated CAFs secrete cytokines such as IL-6 and TGF-, remodel the ECM to create physical barriers, and promote immune evasion through paracrine signaling ( 2.2 Immune evasion mechanisms at the cellular and molecular level osteosarcoma employ multiple strategies to evade immune recognition and destruction

This diversity is critical for understanding how retatrutide performs across different populations

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Daily Function Energy, activity, eating patterns, quality of life, and the ability to continue treatment may also be considered