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With lifestyle modification alone, the weight loss effect is limited to approximately one year, after which weight increases due to endocrine mechanisms involved in body weight regulation [6, 10]

N Engl J Med (2013) 368(2):14960.10.1056/NEJMcp1113996 3 BerlinHBerlinRBranteG

Studies suggest a correlation between using GLP-1 drugs and an increased risk of developing thyroid cancers

Insulin resistance-mediated dysregulation of carnitine transport Beyond direct transport defects, systemic insulin resistance in DKD significantly exacerbates carnitine metabolic imbalance

Supports the nervous system, improves carbohydrate metabolism, and helps the body recover from stress

Patients who continue consuming excessive caloriesparticularly from ultra-processed foods, sugary beverages, and alcoholmay experience minimal weight loss despite medication