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Unlike earlier generation mono-agonists (targeting only GLP-1) or dual-agonists (targeting GLP-1 and GIP), Retatrutide exhibits high affinity for three distinct receptor sites: the glucose-dependent insulinotropic polypeptide (GIP) receptor, the glucagon-like peptide-1 (GLP-1) receptor, and the glucagon (GCG) receptor

The prohibition applies both in-competition and out-of-competition

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The kind that makes the first two days after injection miserable

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