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Nausea that appeared at lower doses may intensify temporarily before adapting

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Sermorelin (sermorelin acetate) is a synthetic peptide consisting of the first 29 amino acids of the 44-amino-acid human GHRH sequence

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This observation suggests that DET1 interacts with both COP1 and Ube2e proteins, facilitating the presentation of Ube2e proteins by DET1 claw to the COP1 RING dimer