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These effects might be facilitated via AMPK/Sirtuin 1 (SIRT1), autophagy, and the Toll-like receptor-4 (TLR-4)/NF-B/NLRP3 signal transduction cascade [264]

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Predrag Sikiric, the lead researcher at the University of Zagreb who has published extensively on BPC-157, stated: "BPC-157 interacts with the NO system as a novel mediator of Robert's cytoprotection, maintaining endothelial integrity across multiple organ systems" [1]

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J Mol Nutr Food Res 9:452461

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10.1183/09031936.04.00120703 Eur Respir J

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