doi: 10.3389/fbioe.2020.00359 Received 17 February 2020 Accepted 31 March 2020 Published 30 April 2020 Volume 8 - 2020 Edited by Roberto Narcisi, Erasmus University Rotterdam, Netherlands Reviewed by Guus van den Akker, Maastricht University, Netherlands
Screening of 16,675 titles and abstracts led to the removal of 15,778 non-relevant studies
We included two cohorts
Phase 1 Trials In a first-in-human, randomized, placebo-controlled, single ascending dose, phase 1 trial in healthy participants, retatrutide demonstrated a favourable safety profile (similar to other incretin-based therapies) and early signs of efficacy with dose-dependent WL [42]
Oral supplements may cause mild digestive discomfort in some individuals, while injectable forms may involve risks such as local irritation at the injection site or allergic reactions in certain cases
Intravenous delivery of glutathione circumvents the body's slow and frequently ineffective digestion process