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Niacin or B3 Taking high-dose niacin supplements can result in skin-related allergic reactions, such as extreme facial flushing, also referred to as niacin flush. Flushing causes generalized itching and a burning sensation that is typically limited to the face and chest and lasts 20 to 30 minutes(1)

This is to ensure rapid replenishment of body stores to prevent irreversible consequences of deficiency

B12 injections can be a game-changer

A GP blood test is the only reliable way to confirm a deficiency, and NICE advises testing anyone on metformin who has a symptom or a risk factor

Semaglutide and tirzepatide are GLP-1 receptor agonists

Each method has its own rules and when to use it