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Chronic cortisol elevation is catabolic and can counteract desired anabolic and lipolytic effects

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Reduced Quantal Size : Under repeated amphetamine exposure, the combination of vesicular NE displacement (via proton gradient collapse) and VMAT2 blockade prevents newly recycled or recruited vesicles from being effectively refilled with NE (Sulzer et al, 1995

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The procedure lasts within 45-60 minutes