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Colchicine is not safe in patients with substantial kidney or liver disease and should not be used along with drugs such as ketoconazole (eg, Nozoral), fluconazole (Diflucan), clarithromycin (Biaxin, an antibiotic), cyclosporine (eg, Sandimmune, an immunosuppressant agent), or ritonavir (Norvir, an antiviral drug) due to the potential for drug-drug interactions
Peptides can alter the potency of other agents
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Erectile dysfunction : Men with B12 deficiency may experience erectile dysfunction as a result of increased levels of homocysteine in the body (28)
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