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Native IGF-1 binds with high affinity to insulin-like growth factor binding proteins (IGFBPs), which sequester the peptide in circulation and substantially reduce its free bioavailable fraction
K.DeBose-BoydR
While systemic injection also delivers peptides to the brain via blood circulation, nasal delivery may provide more direct CNS access for some portion of the dose
There is work on corticotropin, on luteinizing hormone, and on growth hormone release, which places it loosely in neuroendocrine territory alongside its effects on hormonal balance
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