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In recent years, semaglutide has gained FDA approval for chronic weight management under more common brand names like Wegovy and Ozempic (though Ozempic is technically prescribed off-label for weight loss)

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Like other GLP-1 analogues, it acts on GLP-1 receptors to increase insulin secretion and decrease glucagon levels, leading to better blood sugar control and feelings of fullness

Notably, HR-proficient tumours are often harder to treat, owing to their intrinsic resistance to DNA-damaging agents 1