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Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4 methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain

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Since mitochondrial oxidative phosphorylation depends on local NADH availability, whereas cytosolic NADPH supports reductive buffering, disproportionate redistribution between compartments may amplify localized redox imbalance even when total cellular NAD levels appear preserved

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