As depicted in Figure 6, our findings demonstrated a significant downregulation in the expression levels of TNF- and IL-1 upon treatment with GO@GSH-FA
At day 21, four rabbits in the TCC group and three in the zinc oxide group achieved complete coverage with granulation tissue and epithelialization, with mean healing times of 18.4 and 21.5 days, respectively
Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
Spread evenly throughout the body 3
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doi: 10.1111/nph.18655 7 Candela-FerreJ.Diego-MartinB.Prez-AlemanyJ.Gallego-BartolomJ
