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Thymosin beta 4 work centres on G-actin sequestration and integrin-linked kinase signalling, with Bock-Marquette and colleagues (Nature, 2004) reporting cell migration and survival effects in mouse cardiac injury models
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In organotypic hippocampal slice cultures, Dihexa and Nle-AngIV similarly augmented spinogenesis, with control slices showing 7 spines per 50-m dendrite length, compared to 11 for both Dihexa and Nle-AngIV treated slices [2]
It stabilizes intestinal permeability and enhances cytoprotection, making it a promising candidate for mitigating NSAID-induced gastroenteropathy and leaky gut syndrome
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