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Studies looking at NR doses up to 2,000mg per day and NMN doses up to 1,200mg per day found no differences in adverse effects between intervention and placebo groups.31 4 In studies of higher doses that produced adverse effects, typical reactions included:32 Headache Dry mouth GI upset Muscle cramps or spasms As with many forms of vitamin B, NR can cause some flushing, and both NR and NMN can cause digestive upset

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