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Secondary outcomes showed combined resolution of steatohepatitis and fibrosis reduction in 32.7% of semaglutide-treated patients versus 16.1% with placebo (difference, 16.5 percentage points

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Leyden JJ, Stephens TJ, Finkey MB, Appa Y, Barkovic S

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In general, payload release occurs in the TME or after cellular internalization within endosomal/lysosomal compartments, and in some systems may further proceed following endosomal escape, thereby determining the cytosolic availability of the active degrader [184,185,186]

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Retatrutide at the 12 mg dose produced nausea in 38-43% of Phase 3 trial participants

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