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Polydopamine nanoparticles targeting ferroptosis mitigate intervertebral disc degeneration via reactive oxygen species depletion, iron ions chelation, and gpx4 ubiquitination suppression

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Extracellular measurement of RS DCF-DA was used to determine the generation of total RS

doi: 10.3389/fnagi.2026.1729015 Received 20 October 2025 Revised 30 January 2026 Accepted 09 February 2026 Published 27 February 2026 Volume 18 - 2026 Edited by Ashok Kumar, University of Florida, United States Reviewed by Jessica N