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Based on the measured diffusion coefficients and assuming spherical aggregates, the average aggregate volumes for 5 mM and 100 mM samples of protonated SNAC in CDCl (298 K) were calculated to be 0.42 nm 3 and 1.05 nm 3 , respectively, using the Stokes-Einstein relationship
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GRK2+/ mice display increased insulin release during the early but not late phase of insulin secretion Given the specific localization of pancreatic GRK2 inside the islets, we set out to determine whether GRK2 expression could have an impact on islet function, first by investigating early and late phase insulin secretion in response to feeding in WT and GRK2+/ animals
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