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Mild rashes often resolve without stopping the medication, but any rash accompanied by swelling, blistering, or difficulty breathing requires urgent medical evaluation

Discontinuation in trials: retatrutide trial discontinuation due to adverse events was 6-10% across the higher-dose arms meaningful but lower than the dose-related side-effect profile would suggest, which indicates most participants tolerated the protocol

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However, research indicates that liposomal encapsulated tablets may be effective when dosed at 10 mg per day or more [11]