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An overflow of glutamate (the main endogenous excitatory amino in brain, at concentration of 515 mmol glutamate per kg body weight, higher than of any other neurotransmitter) is implicated in major psychiatric illnesses [1, 24,25,26]

Its active site contains a cobalt ion with a + 3 charge at the center

You may want to talk with a doctor about B12 shots if you regularly experience: Persistent fatigue and lethargy Muscle aches and joint pain Loss of appetite Nausea, constipation, diarrhea, or cramping Poor memory or difficulty concentrating Mood swings Can B12 Injections Help With Mood Enhancement and Mental Clarity

In: Bhatt HR, James VHT, Besser GM, Bottazzo GF, Keen H, editors

It is also used to decrease the concentrations of inflammatory cytokines (IL-6, IL-18) as well as involved in increasing the level of serum Ca2+ ions