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Semaglutide has a half-life of approximately 7 days, which means one week after your injection, roughly 50% of the medication remains circulating in your bloodstream

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Abstract Glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide 1 receptor (GLP-1R) are expressed in the central nervous system (CNS) and regulate food intake

Too low means insufficient stimulus