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Scott Isaacs, MD, FACP, FACEs Post Reduced-frequency GLP-1 as a maintenance strategy: in this case series, patients who tapered from weekly semaglutide/tirzepatide to less frequent dosing maintained weight loss, body composition, and metabolic syndrome gains, supporting structured de-escalation to lower burden without sacrificing efficacy
Patients who are not obese, or indeed underweight, will still experience weight loss on these medications, so that needs to be balanced with any other potential health benefit.
More serious potential risks include gallbladder disease and acute pancreatitis (seek urgent medical attention for severe, persistent abdominal pain radiating to the back)
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14: 40710 Kaur S, Zilmer M, Eisen M, Kullisaar T, Rehema A, Vihalemm T
The increase in energy expenditure increases FAO because lipids and fatty acid are the main energy substrates for cellular energy expenditure
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