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Retatrutide titration: 1mg to 12mg The retatrutide titration protocol tested in Phase 3 trials follows a five-step escalation: Weeks 1-4: 1mg weekly Weeks 5-8: 2mg weekly Weeks 9-12: 4mg weekly Weeks 13-16: 8mg weekly Week 17 onward: 12mg weekly (maximum dose) The dose doubles at each step (with the exception of the 1mg to 2mg increase), which is a faster escalation rate than either semaglutide or tirzepatide

(7) Tianqi Liu, Ying Liu, Xiaoyu Zhao, Liguo Zhang, Wei Wang, De Bai, Ya Liao, Zhenyuan Wang, Mi Wang, Jiaheng Zhang, Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application, Bioactive Materials, Volume 32, 2024, Pages 502-513 (8) Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK

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Theres only one category of peptide medications with strong clinical evidence for fat loss: GLP-1 receptor agonists (like semaglutide or tirzepatide)

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