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The whitening process starts inside the skin (dermal layer) going outside (epidermal layer), thats the reason why it takes time to be able to see initial change in your skin tone

By promoting blood vessel growth at repair sites, TB-500 ensures the vascular infrastructure needed to support nerve regeneration

They used moderate concentrations rather than jumping to the highest available

DOI: 10.1007/s00253-008-1437-y 17

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Photoaging and Topical Tretinoin: Therapy, Pathogenesis, and Prevention