Emergency evaluation is warranted for fever with suspected obstruction, anuria, uncontrolled pain/vomiting, or in patients with a solitary kidney or who are pregnant
Among the 58% of adults who say they want to lose weight, nearly one-third (32%) expect to start a prescription GLP-1 drug in 2026, which translates to an estimated 48 million American adults including 9% who say they definitely will and 23% who say they probably will
Inability to keep any fluids down for more than 12 hours despite trying all management strategies
Patients experiencing symptoms potentially attributable to thyroid dysfunction (unexplained fatigue, significant cold intolerance, hair loss, severe constipation) should be evaluated with thyroid function testing, but routine thyroid monitoring is not required for patients without risk factors or symptoms
Retatrutide Phase 2 trial New England Journal of Medicine Peer-reviewed Phase 2 trial data on retatrutide in adults with obesity
Thus in addition to increasing GLP-1 concentration, recent research shows that it also lowers insulin concentration and stabilizes ghrelin levels